| First Author | Xie G | Year | 2019 |
| Journal | Am J Pathol | Volume | 189 |
| Issue | 2 | Pages | 272-282 |
| PubMed ID | 30448405 | Mgi Jnum | J:270396 |
| Mgi Id | MGI:6276373 | Doi | 10.1016/j.ajpath.2018.10.009 |
| Citation | Xie G, et al. (2019) Hepatocyte Peroxisome Proliferator-Activated Receptor alpha Enhances Liver Regeneration after Partial Hepatectomy in Mice. Am J Pathol 189(2):272-282 |
| abstractText | Peroxisome proliferator-activated receptor alpha (PPARalpha) is a key nuclear receptor involved in the control of lipid homeostasis. In rodents, PPARalpha is also a potent hepatic mitogen. Hepatocyte-specific disruption of PPARalpha inhibits agonist-induced hepatocyte proliferation; however, little is known about the exact role of PPARalpha in partial hepatectomy (PHx)-induced liver regeneration. Herein, using hepatocyte-specific PPARalpha-deficient (Ppara(DeltaHep)) mice, the function of hepatocyte PPARalpha in PHx-induced liver regeneration was investigated. PPARalpha protein level and transcriptional activity were increased in the liver after PHx. Compared with the Ppara(fl/fl) mice, Ppara(DeltaHep) mice exhibited significantly reduced hepatocyte proliferation at 32 hours after PHx. Consistently, reduced Ccnd1 and Pcna mRNA and CYCD1 and proliferating cell nuclear antigen protein were observed at 32 hours after PHx in Ppara(DeltaHep) mice. Furthermore, Ppara(DeltaHep) mice showed increased hepatic lipid accumulation and enhanced hepatic triglyceride contents because of impaired hepatic fatty acid beta-oxidation when compared with that observed in Ppara(fl/fl) mice. These results indicate that PPARalpha promotes liver regeneration after PHx, at least partially via regulating the cell cycle and lipid metabolism. |
