| First Author | Suddason T | Year | 2016 |
| Journal | Cell Rep | Volume | 14 |
| Issue | 3 | Pages | 449-457 |
| PubMed ID | 26774476 | Mgi Jnum | J:269855 |
| Mgi Id | MGI:6274116 | Doi | 10.1016/j.celrep.2015.12.047 |
| Citation | Suddason T, et al. (2016) T-Cell-Specific Deletion of Map3k1 Reveals the Critical Role for Mekk1 and Jnks in Cdkn1b-Dependent Proliferative Expansion. Cell Rep 14(3):449-457 |
| abstractText | MAPK signaling is important for T lymphocyte development, homeostasis, and effector responses. To better understand the role of Mekk1 (encoded by Map3k1) in T cells, we conditionally deleted Map3k1 in Lck(Cre/+)Map3k1(f/f) mice, and these display larger iNKT cell populations within the liver, spleen, and bone marrow. Mekk1 signaling controls splenic and liver iNKT cell expansion in response to glycolipid antigen. Lck(Cre/+)Map3k1(f/f) mice have enhanced liver damage in response to glycolipid antigen. Mekk1 regulates Jnk activation in iNKT cells and binds and transfers Lys63-linked poly-ubiquitin onto Carma1. Map3k1 is critical for the regulation of p27(Kip1) (encoded by Cdkn1b). |
