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Publication : TET2 Deficiency Sets the Stage for B-cell Lymphoma.

First Author  Shingleton JR Year  2018
Journal  Cancer Discov Volume  8
Issue  12 Pages  1515-1517
PubMed ID  30510015 Mgi Jnum  J:268225
Mgi Id  MGI:6260084 Doi  10.1158/2159-8290.CD-18-1143
Citation  Shingleton JR, et al. (2018) TET2 Deficiency Sets the Stage for B-cell Lymphoma. Cancer Discov 8(12):1515-1517
abstractText  TET2 is a well-established tumor suppressor in the context of myeloid malignancies, but its role in lymphoma development has been less clear. In this issue of Cancer Discovery, Dominguez and colleagues report that TET2 function is critical for germinal center exit and plasma cell differentiation, and its deficiency can lead to B-cell lymphoma phenotypes.See related article by Dominguez et al., p. 1632.
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