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Publication : The emerging link between cancer, metabolism, and circadian rhythms.

First Author  Masri S Year  2018
Journal  Nat Med Volume  24
Issue  12 Pages  1795-1803
PubMed ID  30523327 Mgi Jnum  J:279696
Mgi Id  MGI:6278245 Doi  10.1038/s41591-018-0271-8
Citation  Masri S, et al. (2018) The emerging link between cancer, metabolism, and circadian rhythms. Nat Med 24(12):1795-1803
abstractText  The circadian clock is a complex cellular mechanism that, through the control of diverse metabolic and gene expression pathways, governs a large array of cyclic physiological processes. Epidemiological and clinical data reveal a connection between the disruption of circadian rhythms and cancer that is supported by recent preclinical data. In addition, results from animal models and molecular studies underscore emerging links between cancer metabolism and the circadian clock. This has implications for therapeutic approaches, and we discuss the possible design of chronopharmacological strategies.
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