| First Author | Fu X | Year | 2016 |
| Journal | Neural Plast | Volume | 2016 |
| Pages | 6720420 | PubMed ID | 28101381 |
| Mgi Jnum | J:271795 | Mgi Id | MGI:6282197 |
| Doi | 10.1155/2016/6720420 | Citation | Fu X, et al. (2016) Loss of Myh14 Increases Susceptibility to Noise-Induced Hearing Loss in CBA/CaJ Mice. Neural Plast 2016:6720420 |
| abstractText | MYH14 is a member of the myosin family, which has been implicated in many motile processes such as ion-channel gating, organelle translocation, and the cytoskeleton rearrangement. Mutations in MYH14 lead to a DFNA4-type hearing impairment. Further evidence also shows that MYH14 is a candidate noise-induced hearing loss (NIHL) susceptible gene. However, the specific roles of MYH14 in auditory function and NIHL are not fully understood. In the present study, we used CRISPR/Cas9 technology to establish a Myh14 knockout mice line in CBA/CaJ background (now referred to as Myh14(-/-) mice) and clarify the role of MYH14 in the cochlea and NIHL. We found that Myh14(-/-) mice did not exhibit significant hearing loss until five months of age. In addition, Myh14(-/-) mice were more vulnerable to high intensity noise compared to control mice. More significant outer hair cell loss was observed in Myh14(-/-) mice than in wild type controls after acoustic trauma. Our findings suggest that Myh14 may play a beneficial role in the protection of the cochlea after acoustic overstimulation in CBA/CaJ mice. |
