| First Author | Ojcius DM | Year | 2019 |
| Journal | PLoS One | Volume | 14 |
| Issue | 4 | Pages | e0215689 |
| PubMed ID | 31013297 | Mgi Jnum | J:275013 |
| Mgi Id | MGI:6303502 | Doi | 10.1371/journal.pone.0215689 |
| Citation | Ojcius DM, et al. (2019) Dicer regulates activation of the NLRP3 inflammasome. PLoS One 14(4):e0215689 |
| abstractText | Inflammation plays a critical role in initiation of adaptive immunity, pathogen clearance and tissue repair. Interleukin (IL)-1beta is a potent pro-inflammatory cytokine and therefore its production is tightly regulated: its secretion requires the assembly of a macromolecular protein complex, termed the inflammasome. Aberrant activation of the inflammasome has been linked to debilitating human diseases including chronic inflammatory and autoimmune diseases. Thus, there is a great interest in understanding how inflammasomes are regulated. Here we show that Dicer, an enzyme necessary for the production of mature micro-RNAs (miRNAs), is required for optimal activation of NLRP3 inflammasomes in bone marrow macrophages. Our data indicate that miRNAs may play an important role in promoting inflammasome activation. |
