| First Author | Fry RC | Year | 2019 |
| Journal | Chem Res Toxicol | Volume | 32 |
| Issue | 8 | Pages | 1487-1490 |
| PubMed ID | 31251040 | Mgi Jnum | J:278191 |
| Mgi Id | MGI:6333057 | Doi | 10.1021/acs.chemrestox.9b00107 |
| Citation | Fry RC, et al. (2019) Effects of Preconception and in Utero Inorganic Arsenic Exposure on the Metabolic Phenotype of Genetically Diverse Collaborative Cross Mice. Chem Res Toxicol |
| abstractText | In humans and mice, in utero exposure to inorganic arsenic (iAs) is associated with adverse health outcomes later in life. The contribution of preconception exposure to the adverse outcomes in offspring has never been studied. Here combined in utero and postnatal exposures produce insulin resistance in two collaborative cross strains. Furthermore, combined preconception and in utero exposure resulted in increased birth weight and developed insulin resistance in one strain. Thus, preconception exposure to arsenic may contribute to the metabolic disorders later in life, but the susceptibility to the effects of this exposure is determined, at least in part, by genetics. |
