| First Author | Le Menn G | Year | 2019 |
| Journal | FASEB J | Volume | 33 |
| Issue | 2 | Pages | 2553-2562 |
| PubMed ID | 30285581 | Mgi Jnum | J:284274 |
| Mgi Id | MGI:6387286 | Doi | 10.1096/fj.201800696RR |
| Citation | Le Menn G, et al. (2019) Decrease in alphabeta/gammadelta T-cell ratio is accompanied by a reduction in high-fat diet-induced weight gain, insulin resistance, and inflammation. FASEB J 33(2):2553-2562 |
| abstractText | The implication of alphabeta and gammadelta T cells in obesity-associated inflammation and insulin resistance (IR) remains uncertain. Mice lacking gammadelta T cells show either no difference or a decrease in high-fat diet (HFD)-induced IR, whereas partial depletion in gammadelta T cells does not protect from HFD-induced IR. alphabeta T-cell deficiency leads to a decrease in white adipose tissue (WAT) inflammation and IR without weight change, but partial depletion of these cells has not been studied. We previously described a mouse model overexpressing peroxisome proliferator-activated receptor beta (PPAR-beta) specifically in T cells [transgenic (Tg) T-PPAR-beta] that exhibits a partial depletion in alphabeta T cells and no change in gammadelta T-cell number. This results in a decreased alphabeta/gammadelta T-cell ratio in lymphoid organs. We now show that Tg T-PPAR-beta mice are partially protected against HFD-induced weight gain and exhibit decreased IR and liver steatosis independently of animal weight. These mice display an alteration of WAT-depots distribution with an increased epididymal-WAT mass and a decreased subcutaneous WAT mass. Immune cell number is decreased in both WAT-depots, except for gammadelta T cells, which are increased in epididymal-WAT. Overall, we show that decreasing alphabeta/gammadelta T-cell ratio in WAT-depots alters their inflammatory state and mass repartition, which might be involved in improvement of insulin sensitivity.-Le Menn, G., Sibille, B., Murdaca, J., Rousseau, A.-S., Squillace, R., Vergoni, B., Cormont, M., Niot, I., Grimaldi, P. A., Mothe-Satney, I., Neels, J. G. Decrease in alphabeta/gammadelta T-cell ratio is accompanied by a reduction in high-fat diet-induced weight gain, insulin resistance, and inflammation. |
