| First Author | Wang L | Year | 2020 |
| Journal | Nat Commun | Volume | 11 |
| Issue | 1 | Pages | 35 |
| PubMed ID | 31911623 | Mgi Jnum | J:283834 |
| Mgi Id | MGI:6387834 | Doi | 10.1038/s41467-019-13734-w |
| Citation | Wang L, et al. (2020) TGF-beta induces ST2 and programs ILC2 development. Nat Commun 11(1):35 |
| abstractText | The molecular pathways underlying the development of innate lymphoid cells (ILCs) are mostly unknown. Here we show that TGF-beta signaling programs the development of ILC2s from their progenitors. Specifically, the deficiency of TGF-beta receptor II in bone marrow progenitors results in inefficient development of ILC2s, but not ILC1s or ILC3s. Mechanistically, TGF-beta signaling is required for the generation and maintenance of ILC2 progenitors (ILC2p). In addition, TGF-beta upregulates the expression of the IL-33 receptor gene Il1rl1 (encoding IL-1 receptor-like 1, also known as ST2) in ILC2p and common helper-like innate lymphoid progenitors (CHILP), at least partially through the MEK-dependent pathway. These findings identify a function of TGF-beta in the development of ILC2s from their progenitors. |
