| First Author | Tang P | Year | 2019 |
| Journal | Biol Open | Volume | 8 |
| Issue | 8 | PubMed ID | 31391163 |
| Mgi Jnum | J:357041 | Mgi Id | MGI:6357758 |
| Doi | 10.1242/bio.043638 | Citation | Tang P, et al. (2019) Unique trophoblast chromatin environment mediated by the PcG protein SFMBT2. Biol Open 8(8) |
| abstractText | Stem/progenitor cells are maintained by a chromatin environment, mediated in part by Polycomb group (PcG) proteins, which depress differentiation. The trophoblast-specific PcG protein SFMBT2 is known to be required for maintenance of trophoblast progenitors. Rather than binding to trophoblast-specific genes repressed in TSC, SFMBT2 is concentrated at chromocentres and regions rich in repetitive elements, specifically LINE sequences and major satellites, suggesting that it is involved in higher-order organization of the trophoblast genome. It is also found enriched at a subset of ncRNAs. Comparison of ChIP-seq datasets for other chromatin proteins reveals several stereotypical distribution patterns, suggesting that SFMBT2 interacts with several different types of chromatin complexes specific to the trophoblast lineage. |
