| First Author | Shao D | Year | 2019 |
| Journal | Mol Med Rep | Volume | 19 |
| Issue | 5 | Pages | 4001-4010 |
| PubMed ID | 30896808 | Mgi Jnum | J:291192 |
| Mgi Id | MGI:6442952 | Doi | 10.3892/mmr.2019.10056 |
| Citation | Shao D, et al. (2019) The function of miRNA153 against isofluraneinduced neurotoxicity via Nrf2/ARE cytoprotection. Mol Med Rep 19(5):4001-4010 |
| abstractText | The present study aimed to investigate the function of micro (mi)RNA153 against isofluraneinduced neurotoxicity and its mechanism. In isofluraneinduced mice, miRNA153 expression was downregulated compared with in the control group. Downregulation of miRNA153 induced neurocyte apoptosis, reduced cell growth and promoted oxidative stress in an in vitro model. Overexpression of miRNA153 reduced oxidative stress, promoted cell growth and inhibited neurocyte apoptosis within an in vitro model. Downregulation of miRNA153 suppressed nuclear erythroid2 related factor 2 (Nrf2)/antioxidant response element (ARE) signaling pathway, which was induced via the overexpression of miRNA153 in vitro. The Nrf2 agonist, dimethyl fumarate (2.5 microM), induced the Nrf2/ARE signaling pathway and reduced oxidative stress to induce neurocyte apoptosis in vitro following treatment with antimiRNA153. The results of the present study suggested the function of miRNA153 against neurotoxicity via Nrf2/AREmediated cytoprotection. |
