| First Author | Zhao Y | Year | 2019 |
| Journal | Biochem Biophys Res Commun | Volume | 515 |
| Issue | 3 | Pages | 474-480 |
| PubMed ID | 31164200 | Mgi Jnum | J:291810 |
| Mgi Id | MGI:6443177 | Doi | 10.1016/j.bbrc.2019.05.151 |
| Citation | Zhao Y, et al. (2019) Nitrosporeusine A attenuates sepsis-associated acute kidney injury through the downregulation of IL-6/sIL-6R axis activation-mediated PGC-1alpha suppression. Biochem Biophys Res Commun 515(3):474-480 |
| abstractText | Nitrosporeusine A (NA) has been recently reported to exert anti-inflammatory and renal protective effects, but whether NA can attenuate sepsis-associated acute kidney injury (AKI) has not yet been reported. In this study, our results found that cecal ligation and puncture (CLP) reduced renal PGC-1alpha expression and induced oxidative stress in C57BL/6 mice. PGC-1alpha overexpression attenuated CLP-induced AKI with decreased oxidative stress, whereas worsened AKI with excessive reactive oxygen species (ROS) production was observed in renal specific PGC-1alpha knockout (NiPKO) mice. In addition, PGC-1alpha expression is retained in IL-6(-/-) mice and wild-type (WT) C57BL/6 mice received JAK2/STAT3 inhibition. Finally, administration of NA attenuated CLP-induced AKI with decreased IL-6/sIL-6R axis activation, increased PGC-1alpha expression, and diminished ROS production in injured kidneys. However, NA failed to attenuate CLP-induced AKI in NiPKO mice. Together, these results suggested that NA attenuates sepsis-associated AKI through the downregulation of IL-6/sIL-6R axis activation-mediated renal PGC-1alpha suppression. |
