| First Author | Qin C | Year | 2019 |
| Journal | Biochem Biophys Res Commun | Volume | 513 |
| Issue | 1 | Pages | 248-254 |
| PubMed ID | 30954227 | Mgi Jnum | J:300639 |
| Mgi Id | MGI:6442095 | Doi | 10.1016/j.bbrc.2019.03.184 |
| Citation | Qin C, et al. (2019) Uncoupling nNOS-PSD-95 in the ACC can inhibit contextual fear generalization. Biochem Biophys Res Commun 513(1):248-254 |
| abstractText | A typical feature of the contextual fear memory is increased fear generalization with time. Though much attention has been given to the neural structures that underlie the long-term consolidation of a contextual fear memory, the molecular mechanisms regulating fear generalization remain unclear. We observed that retrieval of contextual fear in a novel context at a remote time point increased coupling of neuronal nitric oxide synthase (nNOS) with postsynaptic density-95 (PSD-95) and c-Fos expression in the anterior cingulate cortex (ACC). Disrupting nNOS-PSD-95 coupling in the ACC decreased the expression of Histone deacetylase 2 (HDAC2), and inhibited contextual fear generalization at a remote time point. Together, our findings reveal nNOS-PSD-95 interaction in the ACC could be a promising target to prevent or reverse contextual fear generalization. |
