| First Author | Molinaro A | Year | 2019 |
| Journal | Mol Metab | Volume | 23 |
| Pages | 82-87 | PubMed ID | 30904385 |
| Mgi Jnum | J:290275 | Mgi Id | MGI:6442220 |
| Doi | 10.1016/j.molmet.2019.02.010 | Citation | Molinaro A, et al. (2019) Liver-specific RORalpha deletion does not affect the metabolic susceptibility to western style diet feeding. Mol Metab 23:82-87 |
| abstractText | OBJECTIVES: The nuclear receptor superfamily is a potential target for the development of new treatments for obesity and metabolic diseases. Increasing evidence has pointed towards the retinoic acid-related orphan receptor-alpha (RORalpha) as an important nuclear receptor involved in several biological processes. RORalpha full body knockout mice display improved metabolic phenotypes on both chow and high fat (60% fat, 20% carbohydrate) diets, but also have severe behavioral abnormalities. Here we investigated the effect of hepatic RORalpha by generating mice with liver-specific RORalpha deletion to elucidate the role of this nuclear receptor on host metabolism. METHODS: 8 week-old mice with liver-specific RORalpha deletion and littermate controls were fed either chow or western-style diets (40% fat, 40% carbohydrate) for 12 weeks. Metabolic phenotyping was performed at the end of the dietary intervention. RESULTS: Here, we show that hepatic RORalpha deletion does not affect the metabolic susceptibility to either chow or western-style diet in terms of glucose metabolism and adiposity. CONCLUSIONS: Our data indicate that liver deletion of RORalpha does not have a pivotal role in the regulation of hepatic glucose and lipid metabolism on chow or western-style diet. |
