| First Author | Zhou Z | Year | 2020 |
| Journal | Science | Volume | 368 |
| Issue | 6486 | Pages | 54-60 |
| PubMed ID | 32193362 | Mgi Jnum | J:286589 |
| Mgi Id | MGI:6402841 | Doi | 10.1126/science.aay2494 |
| Citation | Zhou Z, et al. (2020) Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes. Science 368(6486):54-60 |
| abstractText | The endoplasmic reticulum (ER) engages mitochondria at specialized ER domains known as mitochondria-associated membranes (MAMs). Here, we used three-dimensional high-resolution imaging to investigate the formation of pleomorphic "megamitochondria" with altered MAMs in brown adipocytes lacking the Sel1L-Hrd1 protein complex of ER-associated protein degradation (ERAD). Mice with ERAD deficiency in brown adipocytes were cold sensitive and exhibited mitochondrial dysfunction. ERAD deficiency affected ER-mitochondria contacts and mitochondrial dynamics, at least in part, by regulating the turnover of the MAM protein, sigma receptor 1 (SigmaR1). Thus, our study provides molecular insights into ER-mitochondrial cross-talk and expands our understanding of the physiological importance of Sel1L-Hrd1 ERAD. |
