| First Author | Xie W | Year | 2020 |
| Journal | World Neurosurg | PubMed ID | 32200014 |
| Mgi Jnum | J:286442 | Mgi Id | MGI:6403566 |
| Doi | 10.1016/j.wneu.2020.03.063 | Citation | Xie W, et al. (2020) OIP5-AS1 attenuates microangiopathy in diabetic mouse by regulating miR-200b/ACE2. World Neurosurg |
| abstractText | This study aimed to investigate OIP5-AS1 effects on microangiopathy in diabetic mouse. Our results indicated that diabetic mice exhibited much lower OIP5-AS1 expression in the hippocampus than normal mice. Diabetic mice of OIP5-AS1 KO group showed remarkably lower OIP5-AS1 expression in the hippocampus, longer escape latency and lower percentage of CD31+ cells in the hippocampusthan those of WT group. OIP5-AS1 knockdown directly up-regulated miR-200b expression and ACE2 was directly inhibited by miR-200b. Relative to normal mice, diabetic mice had markedly higher miR-200b expression and lower ACE2 expression in the hippocampus. Diabetic mice of OIP5-AS1 KO group were with obviously higher miR-200b expression and lower ACE2 expression in the hippocampus than those of WT group. Compared with diabetic mice of OIP5-AS1 KO group, those of WT group, OIP5-AS1 KO + miR-200b inhibitor group and OIP5-AS1 KO + ACE2 group had obviously shorter escape latency and higher percentage of CD31(+) cells and more caspase-3 protein expression in the hippocampus. In conclusion, OIP5-AS1 attenuated microangiopathy in diabetic mouse by regulating miR-200b/ACE2. |
