| First Author | Brykczynska U | Year | 2020 |
| Journal | Cell Rep | Volume | 30 |
| Issue | 5 | Pages | 1627-1643.e7 |
| PubMed ID | 32023474 | Mgi Jnum | J:288128 |
| Mgi Id | MGI:6415751 | Doi | 10.1016/j.celrep.2020.01.005 |
| Citation | Brykczynska U, et al. (2020) Distinct Transcriptional Responses across Tissue-Resident Macrophages to Short-Term and Long-Term Metabolic Challenge. Cell Rep 30(5):1627-1643.e7 |
| abstractText | The innate immune system safeguards the organism from both pathogenic and environmental stressors. Also, physiologic levels of nutrients affect organismal and intra-cellular metabolism and challenge the immune system. In the long term, over-nutrition leads to low-grade systemic inflammation. Here, we investigate tissue-resident components of the innate immune system (macrophages) and their response to short- and long-term nutritional challenges. We analyze the transcriptomes of six tissue-resident macrophage populations upon acute feeding and identify adipose tissue macrophages and the IL-1 pathway as early sensors of metabolic changes. Furthermore, by comparing functional responses between macrophage subtypes, we propose a regulatory, anti-inflammatory role of heat shock proteins of the HSP70 family in response to long- and short-term metabolic challenges. Our data provide a resource for assessing the impact of nutrition and over-nutrition on the spectrum of macrophages across tissues with a potential for identification of systemic responses. |
