| First Author | Frempah B | Year | 2019 |
| Journal | J Immunol Res | Volume | 2019 |
| Pages | 6276254 | PubMed ID | 31781680 |
| Mgi Jnum | J:289956 | Mgi Id | MGI:6435244 |
| Doi | 10.1155/2019/6276254 | Citation | Frempah B, et al. (2019) IL-6 Negatively Regulates IL-22Ralpha Expression on Epidermal Keratinocytes: Implications for Irritant Contact Dermatitis. J Immunol Res 2019:6276254 |
| abstractText | Irritant Contact Dermatitis (ICD) is characterized by epidermal hyperplasia and inflammatory cytokine release. IL-6 has been shown to be involved in the pathogenesis of ICD; however, the involvement of the IL-22/IL-22Ralpha axis and its relation to IL-6 in the inflammatory response following irritant exposure are unknown. Using a chemical model of ICD, it was observed that mice with a keratinocyte-specific knockout of IL-6Ralpha (IL-6Ralpha (Deltaker)) presented with increased inflammation and IL-22Ralpha and IL-22 protein expression relative to WT following irritant exposure, indicating that IL-6Ralpha deficiency in epidermal keratinocytes leads to the upregulation of IL-22Ralpha and its ligand during ICD. Furthermore, it was shown that IL-6 negatively regulates the expression of IL-22Ralpha on epidermal keratinocytes. This effect is functional as the effects of IL-22 on keratinocyte proliferation and differentiation were markedly reduced when keratinocytes were pretreated with IL-6 prior to IL-22 treatment. These results show that IL-6 modulates the IL-22/IL-22Ralpha axis in the skin and suggest that this occurrence may be associated with the increased epidermal hyperplasia and exacerbated inflammatory response observed in IL-6Ralpha (Deltaker) mice during ICD. |
