| First Author | Huang XT | Year | 2019 |
| Journal | Int J Mol Med | Volume | 44 |
| Issue | 6 | Pages | 2213-2222 |
| PubMed ID | 31661121 | Mgi Jnum | J:290093 |
| Mgi Id | MGI:6435282 | Doi | 10.3892/ijmm.2019.4387 |
| Citation | Huang XT, et al. (2019) Dihydroartemisinin attenuates lipopolysaccharideinduced acute lung injury in mice by suppressing NFkappaB signaling in an Nrf2dependent manner. Int J Mol Med 44(6):2213-2222 |
| abstractText | Acute lung injury (ALI) is a severe health issue with significant morbidity and mortality. Artemisinin is used for the treatment of fever and malaria in clinical practice. Dihydroartemisinin (DHA), the major active metabolite of artemisinin, plays a role in antiorganizational fibrosis and antineuronal cell death. However, whether DHA can attenuate ALI remains unclear. The current study thus examined the effects of DHA on ALI and primary macrophages. The results revealed that DHA attenuated lipopolysaccharide (LPS)induced pulmonary pathological damage. DHA suppressed the LPSinduced infiltration of inflammatory cells, the elevation of myeloperoxidase activity, oxidative stress and the production of proinflammatory cytokines, including interleukin (IL)1beta, tumor necrosis factoralpha, and IL6. Furthermore, DHA reduced the LPSinduced inflammatory response by suppressing the degradation of IkappaB and the nuclear translocation of nuclear factor kappalightchainenhancer of activated B cells (NFkappaB)/p65 in vivo and in vitro. DHA activated the nuclear factorerythroid 2 related factor 2 (Nrf2) pathway, which was suppressed by LPS treatment. The Nrf2 inhibitor, ML385, diminished the protective effects of DHA against LPSinduced inflammation in macrophages. On the whole, the findings of this study demonstrate that DHA exerts therapeutic effects against LPSinduced ALI by inhibiting the Nrf2mediated NFkappaB activation in macrophages. The present study also confirmed the therapeutic effects of DHA in mice with LPSinduced ALI. Thus, these findings demonstrate that DHA exhibits antiinflammatory activities and may be a therapeutic candidate for the treatment of ALI. |
