| First Author | Chen ELY | Year | 2019 |
| Journal | Nat Immunol | Volume | 20 |
| Issue | 11 | Pages | 1456-1468 |
| PubMed ID | 31636466 | Mgi Jnum | J:292398 |
| Mgi Id | MGI:6449014 | Doi | 10.1038/s41590-019-0518-7 |
| Citation | Chen ELY, et al. (2019) RBPJ-dependent Notch signaling initiates the T cell program in a subset of thymus-seeding progenitors. Nat Immunol 20(11):1456-1468 |
| abstractText | T cell specification and commitment require Notch signaling. Although the requirement for Notch signaling during intrathymic T cell development is known, it is still unclear whether the onset of T cell priming can occur in a prethymic niche and whether RBPJ-dependent Notch signaling has a role during this event. Here, we established an Rbpj-inducible system that allowed temporal and tissue-specific control of the responsiveness to Notch in all hematopoietic cells. Using this system, we found that Notch signaling was required before the early T cell progenitor stage in the thymus. Lymphoid-primed multipotent progenitors in the bone marrow underwent Notch signaling with Rbpj induction, which inhibited development towards the myeloid lineage in thymus-seeding progenitors. Thus, our results indicated that the onset of T cell differentiation occurred in a prethymic setting, and that Notch played an important role during this event. |
