| First Author | Muha V | Year | 2019 |
| Journal | Open Biol | Volume | 9 |
| Issue | 11 | Pages | 190192 |
| PubMed ID | 31771416 | Mgi Jnum | J:293119 |
| Mgi Id | MGI:6451270 | Doi | 10.1098/rsob.190192 |
| Citation | Muha V, et al. (2019) Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice. Open Biol 9(11):190192 |
| abstractText | O-GlcNAcylation is an abundant post-translational modification in the nervous system, linked to both neurodevelopmental and neurodegenerative disease. However, the mechanistic links between these phenotypes and site-specific O-GlcNAcylation remain largely unexplored. Here, we show that Ser517 O-GlcNAcylation of the microtubule-binding protein Collapsin Response Mediator Protein-2 (CRMP2) increases with age. By generating and characterizing a Crmp2(S517A) knock-in mouse model, we demonstrate that loss of O-GlcNAcylation leads to a small decrease in body weight and mild memory impairment, suggesting that Ser517 O-GlcNAcylation has a small but detectable impact on mouse physiology and cognitive function. |
