| First Author | Gao Y | Year | 2019 |
| Journal | Mol Neurobiol | Volume | 56 |
| Issue | 11 | Pages | 7508-7521 |
| PubMed ID | 31044367 | Mgi Jnum | J:295533 |
| Mgi Id | MGI:6453931 | Doi | 10.1007/s12035-019-1618-y |
| Citation | Gao Y, et al. (2019) MicroRNA miR-7 and miR-17-92 in the Arcuate Nucleus of Mouse Hypothalamus Regulate Sex-Specific Diet-Induced Obesity. Mol Neurobiol 56(11):7508-7521 |
| abstractText | Proper appetite, energy expenditure, and glucose and fat metabolisms are regulated by neurons in the arcuate nucleus (ARC) of mammalian hypothalamus. Studies have shown sex-specific difference in diet-induced obesity, but the underlying mechanisms remain unclear. Here, we show that microRNA (miRNA) miR-7 and miR-17-92 are expressed in proopiomelanocortin (POMC)-expressing neurons in the mouse ARC. Specific knockdown of miR-7 and knockout of miR-17-92 in POMC-expressing neurons aggravate diet-induced obesity only in females and males, respectively. Sex-differentially expressed genes are identified in the male and female ARC of wild-type adult mice using RNA sequencing. Interestingly, some target genes for miR-7 and miR-17-92 not only display sex-differential expression in the male and female ARC but also respond to high-fat diet treatment in miR-7 knockdown and miR-17-92 knockout mice. Our results demonstrate an important role of miRNAs in regulating sex-specific diet-induced obesity, likely through modulating expression of target genes that show sex-differential expression in the ARC of the hypothalamus. |
