| First Author | Bai Y | Year | 2019 |
| Journal | Acta Histochem | Volume | 121 |
| Issue | 3 | Pages | 323-329 |
| PubMed ID | 30777303 | Mgi Jnum | J:295574 |
| Mgi Id | MGI:6453980 | Doi | 10.1016/j.acthis.2019.02.001 |
| Citation | Bai Y, et al. (2019) Effects of myostatin deficiency on PGC-1alpha and FNDC5 expression in three different murine muscle types. Acta Histochem 121(3):323-329 |
| abstractText | Myostatin (MSTN) is a key negative regulator of muscle growth and development. Skeletal, cardiac, and smooth muscles were isolated from MSTN knockout (MSTN--) and control mice to investigate the effect of knocking out MSTN on peroxisome proliferator-activated receptor 1 coactivator (PGC-1alpha)-III and fibronectin domain 5 (FNDC5) expression. Various molecular biology techniques were used to analyze the changes in PGC-1alpha-FNDC5 in different muscle types from MSTN-- mice. The expression levels of PGC-1alpha and FNDC5 in the skeletal, cardiac, and smooth muscles of MSTN-- mice differed from those in the skeletal, cardiac, and smooth muscles of normal mice. This study revealed that knocking out MSTN resulted in inconsistent PGC-1alpha and FNDC5 expression in specific muscles. It proved for the first time that MSTN deletion attenuated the expression of PGC-1alpha and FNDC5 in three different murine muscle types. MSTN deletion may have additional effects on the status ofFNDC5 expression. Further research, however, is needed to confirm this conclusion. |
