| First Author | Piobbico D | Year | 2018 |
| Journal | Cell Cycle | Volume | 17 |
| Issue | 21-22 | Pages | 2423-2435 |
| PubMed ID | 30395772 | Mgi Jnum | J:295641 |
| Mgi Id | MGI:6454162 | Doi | 10.1080/15384101.2018.1542893 |
| Citation | Piobbico D, et al. (2018) Role of IL-17RA in the proliferative priming of hepatocytes in liver regeneration. Cell Cycle 17(21-22):2423-2435 |
| abstractText | A tight link has been established between inflammation and cancer. Liver regeneration is a widely used model to study the correlation between inflammation and proliferation. IL-6 is essentially involved in liver regeneration and in cancer. Recently, IL-17A has been shown to regulate not only inflammation, but also cell proliferation. Here, we analyze the role played by IL-17A signaling in liver regeneration by comparing cell proliferation in Wild Type and IL-17RA(-/-) mice. Partial hepatectomy experiments performed in IL-17RA(-/-) mice showed a delay in expression of early-genes to prime the residual hepatocyte to proliferate, with subsequent delay in G1/S-phase transition. We demonstrated that IL-17RA regulates, by recruitment of non-parenchymal cell, the expression of IL-6, which in turn triggers the proliferation of residual hepatocytes. Our data indicate an important role played by IL-17RA in liver proliferation via IL-6. |
