| First Author | Nakamae S | Year | 2019 |
| Journal | Parasitol Int | Volume | 70 |
| Pages | 5-15 | PubMed ID | 30639137 |
| Mgi Jnum | J:295660 | Mgi Id | MGI:6454186 |
| Doi | 10.1016/j.parint.2019.01.003 | Citation | Nakamae S, et al. (2019) Role of IL-10 in inhibiting protective immune responses against infection with heterologous Plasmodium parasites. Parasitol Int 70:5-15 |
| abstractText | Malaria is induced by infection with Plasmodium parasites, which are genetically diverse, and the immune response to Plasmodium infection has both allele-specific and cross-reactive components. To determine the role of the cross-reactive immune response in the protection and disease manifestation in heterologous Plasmodium infection, we used infection models of P. chabaudi chabaudi (Pcc) and P. berghei ANKA (PbA). CD4(+) T cells primed with Pcc infection exhibited strong cross-reactivity to PbA antigens. We infected C57BL/6 mice with Pcc and subsequently treated them with an anti-Plasmodium drug. The Pcc-primed mice exhibited reduced parasitemia and showed no signs of experimental cerebral malaria after infection with PbA. CD4(+) T cells from the Pcc-primed mice produced high levels of IFN-gamma and IL-10 in response to PbA early after PbA infection. The blockade of IL-10 signaling with anti-IL-10 receptor antibody increased the proportion of activated CD4(+) and gammadelta T cells and the IFN-gamma production by CD4(+) T cells in response to PbA antigens, while markedly reducing the levels of parasitemia. In contrast, IL-10 blockade did not have a significant effect on parasitemia levels in unprimed mice after PbA infection. These data suggest a potent regulatory role of IL-10 in the cross-reactive memory response to the infection with heterologous Plasmodium parasites leading to the inhibition of the protective immunity and pathogenesis. |
