| First Author | Khotskin NV | Year | 2019 |
| Journal | Behav Brain Res | Volume | 359 |
| Pages | 446-456 | PubMed ID | 30447239 |
| Mgi Jnum | J:295703 | Mgi Id | MGI:6454248 |
| Doi | 10.1016/j.bbr.2018.11.013 | Citation | Khotskin NV, et al. (2019) On association of the lethal yellow (A(Y)) mutation in the agouti gene with the alterations in mouse brain and behavior. Behav Brain Res 359:446-456 |
| abstractText | Lethal yellow (A(Y)) mutation causes obesity and type-2 diabetes in mice. Here we studied the effect of the A(Y) mutation on the brain and behavior. The experiments were carried out on adult (11-12 weeks old) males of A(Y)/a mice and their wild-type littermates (a/a). Mice of A(Y)/a and a/a genotypes did not differ in their home cage activity, sleep, food and water consumption, learning ability in the Morris water maze, anxiety in the open field and elevated plus-maze, as well as in the level of monoamines, metabolites and some genes expression in the brain. At the same time, the fat mass, depressive-like immobility in the forced swim and tail suspension tests were significantly increased in A(Y)/a mice compared with a/a ones. Magnetic resonance imaging revealed a significant reduction of cortex volume in A(Y)/a mice. The level of mRNA of Ptpn5 gene encoding striatal enriched tyrosine phosphatase in the frontal cortex of A(Y)/a mice was significantly elevated compared with their wild-type littermates. This is the first report on the alterations in the brain and behavior in the A(Y)/a mouse line. It is tempting to speculate that this mouse line can serve as a new and useful preclinical model to study neurobehavioral complications associated with obesity and type-2 diabetes. |
