| First Author | Bouderlique T | Year | 2019 |
| Journal | Front Immunol | Volume | 10 |
| Pages | 455 | PubMed ID | 30936870 |
| Mgi Jnum | J:294957 | Mgi Id | MGI:6458207 |
| Doi | 10.3389/fimmu.2019.00455 | Citation | Bouderlique T, et al. (2019) The Concerted Action of E2-2 and HEB Is Critical for Early Lymphoid Specification. Front Immunol 10:455 |
| abstractText | The apparition of adaptive immunity in Gnathostomata correlates with the expansion of the E-protein family to encompass E2-2, HEB, and E2A. Within the family, E2-2 and HEB are more closely evolutionarily related but their concerted action in hematopoiesis remains to be explored. Here we show that the combined disruption of E2-2 and HEB results in failure to express the early lymphoid program in Common lymphoid precursors (CLPs) and a near complete block in B-cell development. In the thymus, Early T-cell progenitors (ETPs) were reduced and T-cell development perturbed, resulting in reduced CD4 T- and increased gammadelta T-cell numbers. In contrast, hematopoietic stem cells (HSCs), erythro-myeloid progenitors, and innate immune cells were unaffected showing that E2-2 and HEB are dispensable for the ancestral hematopoietic lineages. Taken together, this E-protein dependence suggests that the appearance of the full Gnathostomata E-protein repertoire was critical to reinforce the gene regulatory circuits that drove the emergence and expansion of the lineages constituting humoral immunity. |
