| First Author | Dimitrakopoulos FD | Year | 2020 |
| Journal | Cancer Res | Volume | 80 |
| Issue | 19 | Pages | 4025-4036 |
| PubMed ID | 32616502 | Mgi Jnum | J:296624 |
| Mgi Id | MGI:6467581 | Doi | 10.1158/0008-5472.CAN-19-3578 |
| Citation | Dimitrakopoulos FD, et al. (2020) The Fire Within: NF-kappaB Involvement in Non-Small Cell Lung Cancer. Cancer Res 80(19):4025-4036 |
| abstractText | Thirty-four years since its discovery, NF-kappaB remains a transcription factor with great potential for cancer therapy. However, NF-kappaB-targeted therapies have yet to find a way to be clinically translatable. Here, we focus exclusively on the role of NF-kappaB in non-small cell lung cancer (NSCLC) and discuss its contributing effect on cancer hallmarks such as inflammation, proliferation, survival, apoptosis, angiogenesis, epithelial-mesenchymal transition, metastasis, stemness, metabolism, and therapy resistance. In addition, we present our current knowledge of the clinical significance of NF-kappaB and its involvement in the treatment of patients with NSCLC with chemotherapy, targeted therapies, and immunotherapy. |
