| First Author | Palchevskiy V | Year | 2019 |
| Journal | JCI Insight | Volume | 5 |
| PubMed ID | 31085832 | Mgi Jnum | J:296740 |
| Mgi Id | MGI:6468809 | Doi | 10.1172/jci.insight.121782 |
| Citation | Palchevskiy V, et al. (2019) CCR4 expression on host T cells is a driver for alloreactive responses and lung rejection. JCI Insight 5 |
| abstractText | Despite current immunosuppressive strategies, long-term lung transplant outcomes remain poor due to rapid allogenic responses. Using a stringent mouse model of allo-airway transplantation, we identify the CCR4-ligand axis as a central node driving secondary lymphoid tissue homing and activation of the allogeneic T cells that prevent long-term allograft survival. CCR4 deficiency on transplant recipient T cells diminishes allograft injury and when combined with CTLA4-Ig leads to an unprecedented long-term lung allograft accommodation. Thus, we identify CCR4-ligand interactions as a central mechanism driving allogeneic transplant rejection and suggest it as a potential target to enhance long-term lung transplant survival. |
