| First Author | Fratini E | Year | 2019 |
| Journal | Int J Oncol | Volume | 55 |
| Issue | 5 | Pages | 1149-1156 |
| PubMed ID | 31545418 | Mgi Jnum | J:298334 |
| Mgi Id | MGI:6472122 | Doi | 10.3892/ijo.2019.4878 |
| Citation | Fratini E, et al. (2019) Link between spermine oxidase and apoptosis antagonizing transcription factor: A new pathway in neuroblastoma. Int J Oncol 55(5):1149-1156 |
| abstractText | Neuroblastoma (NB) is a heterogeneous extracranial childhood type of cancer, responsible for approximately 15% of all paediatric cancerrelated deaths. Although several critical genetic aberrations have been related to NB, only a few established molecular markers have been associated with prognosis [Vmyc avian myelocytomatosis viral oncogene (MYCN) locus amplification, deletions of part of chromosome 1p, 11q23 and gain of 17q]. Regrettably, direct evidence of NBrelated tumour suppressors or oncogenes has not been currently identified at these chromosomal regions. MYCN locus amplification is present in approximately 2030% of cases and is associated with a poor clinical outcome, representing the most important genetic prognostic marker. The functional guidelines for the prognosis of NB identify highrisk patients (<40% survival probabilities), but fail to identify patients at low and intermediate stages of the disease, which remains an issue to be resolved in NB. It has been shown that in NB cell lines and in a totalspermine oxidase (SMOX) transgenic mouse model, SMOX overexpression induces cellular stress via reactive oxygen species (ROS) imbalance. In this study, we demonstrated that the high expression level of the cytoprotective gene, apoptosis-antagonizing transcription factor (AATF), was driven by SMOX gene overexpression in both NB cells and TotalSMOX mice. The antiapoptotic effect of AATF was supported by analysing the inhibition of the expression of the proapoptotic genes, BAX, BAK and PUMA, which were decreased, in both the in vitro and in vivo SMOX overexpressing model systems investigated. On the whole, this study supports the hypothesis that the SMOX gene can be considered as a novel antiapoptotic marker in NB. |
