| First Author | Yang BB | Year | 2020 |
| Journal | Adv Wound Care (New Rochelle) | Volume | 9 |
| Issue | 5 | Pages | 233-244 |
| PubMed ID | 32226648 | Mgi Jnum | J:298435 |
| Mgi Id | MGI:6480115 | Doi | 10.1089/wound.2018.0890 |
| Citation | Yang BB, et al. (2020) Suppressor of Fused Inhibits Skin Wound Healing. Adv Wound Care (New Rochelle) 9(5):233-244 |
| abstractText | Objectives: To investigate the effect of suppressor of fused (Sufu) on epidermal and dermal cellular properties and in wound healing. Approach: Transgenic (TG) mice overexpressing human Sufu (hSufu) in the epidermis were applied to investigate the effects of Sufu on epidermal and dermal cellular properties and in wound healing. Results: Histological staining revealed a reduction of epidermal and dermal thickness and an increase of hypodermal adipose tissue in homozygous K14-hSufu TG mice when compared with wild-type (WT) controls. TG mice exhibited significantly delayed skin wound healing. Moreover, the migratory and proliferative capabilities of cultured keratinocytes were decreased in K14-hSufuTG mice. Transforming growth factor-beta treatment increased the expression of alpha-smooth muscle actin more in WT than in TG fibroblasts. Sufu overexpression significantly decreased the expression of beta-catenin, glioma transcription factor 1 (Gli1), and matrix metalloproteinase-3 in wounds of K14-hSufu TG mice when compared with controls, probably indicating a delaying effect of Sufu on wound healing via blocking the hedgehog (Hh)/Gli and Wnt/beta-catenin pathway. Innovation: Our results indicate a new property of Sufu in the process of skin wound healing. It provides an important basis for Sufu as a potential target for skin wound healing. Conclusion: Our findings suggest that Sufu overexpression in the epidermis impairs wound healing via dampening the Hh/Gli and Wnt/beta-catenin signaling pathway. These data provide an important basis for further analyses of Sufu in skin wound healing. |
