| First Author | Park P | Year | 2021 |
| Journal | Nat Commun | Volume | 12 |
| Issue | 1 | Pages | 413 |
| PubMed ID | 33462202 | Mgi Jnum | J:300905 |
| Mgi Id | MGI:6504751 | Doi | 10.1038/s41467-020-20523-3 |
| Citation | Park P, et al. (2021) PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus. Nat Commun 12(1):413 |
| abstractText | Long-term potentiation (LTP) at hippocampal CA1 synapses can be expressed by an increase either in the number (N) of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors or in their single channel conductance (gamma). Here, we have established how these distinct synaptic processes contribute to the expression of LTP in hippocampal slices obtained from young adult rodents. LTP induced by compressed theta burst stimulation (TBS), with a 10 s inter-episode interval, involves purely an increase in N (LTPN). In contrast, either a spaced TBS, with a 10 min inter-episode interval, or a single TBS, delivered when PKA is activated, results in LTP that is associated with a transient increase in gamma (LTPgamma), caused by the insertion of calcium-permeable (CP)-AMPA receptors. Activation of CaMKII is necessary and sufficient for LTPN whilst PKA is additionally required for LTPgamma. Thus, two mechanistically distinct forms of LTP co-exist at these synapses. |
