| First Author | Suto JI | Year | 2017 |
| Journal | Congenit Anom (Kyoto) | Volume | 57 |
| Issue | 2 | Pages | 57-60 |
| PubMed ID | 28079294 | Mgi Jnum | J:303150 |
| Mgi Id | MGI:6511532 | Doi | 10.1111/cga.12199 |
| Citation | Suto JI (2017) Locus on chromosome 16 is significantly associated with increased tendency to lose pups in females of the RR/Sgn inbred mouse strain. Congenit Anom (Kyoto) 57(2):57-60 |
| abstractText | Females of the inbred mouse strain RR/Sgn have an apparent tendency to lose pups during rearing. To identify genes underlying this abnormal maternal phenotype, we performed quantitative trait loci (QTL) mapping in 349 (C57BL/6 J x RR/Sgn) F1 x RR/Sgn backcross mice and identified one significant and one suggestive QTL on chromosomes 16 and 4, respectively. We assigned the gene symbol nurturing ability QTL 3 (Naq3) to the QTL on chromosome 16. Twenty of the 21 mothers who lost entire litters were homozygous for RR/Sgn allele at Naq3; i.e., the significant association of Naq3 with pup loss was further confirmed by binomial tests. We tentatively propose that Mapk1, Kalrn, and Vps8 are potential candidate genes for Naq3. |
