| First Author | Vono M | Year | 2019 |
| Journal | Cell Rep | Volume | 28 |
| Issue | 7 | Pages | 1773-1784.e5 |
| PubMed ID | 31412246 | Mgi Jnum | J:300464 |
| Mgi Id | MGI:6489056 | Doi | 10.1016/j.celrep.2019.07.047 |
| Citation | Vono M, et al. (2019) Maternal Antibodies Inhibit Neonatal and Infant Responses to Vaccination by Shaping the Early-Life B Cell Repertoire within Germinal Centers. Cell Rep 28(7):1773-1784.e5 |
| abstractText | Maternal antibodies (MatAbs) protect offspring from infections but limit their responses to vaccination. The mechanisms of this inhibition are still debated. Using murine early-life immunization models mimicking the condition prevailing in humans, we observed the induction of CD4-T, T follicular helper, and germinal center (GC) B cell responses even when early-life antibody responses were abrogated by MatAbs. GC B cells induced in the presence of MatAbs form GC structures and exhibit canonical GC changes in gene expression but fail to differentiate into plasma cells and/or memory B cells in a MatAb titer-dependent manner. Furthermore, GC B cells elicited in the presence or absence of MatAbs use different VH and Vk genes and show differences in genes associated with B cell differentiation and isotype switching. Thus, MatAbs do not prevent B cell activation but control the output of the GC reaction both quantitatively and qualitatively, shaping the antigen-specific B cell repertoire. |
