| First Author | Gyukity-Sebestyén E | Year | 2019 |
| Journal | Front Immunol | Volume | 10 |
| Pages | 2459 | PubMed ID | 31681332 |
| Mgi Jnum | J:297827 | Mgi Id | MGI:6479307 |
| Doi | 10.3389/fimmu.2019.02459 | Citation | Gyukity-Sebestyen E, et al. (2019) Melanoma-Derived Exosomes Induce PD-1 Overexpression and Tumor Progression via Mesenchymal Stem Cell Oncogenic Reprogramming. Front Immunol 10:2459 |
| abstractText | Recently, it has been described that programmed cell death protein 1 (PD-1) overexpressing melanoma cells are highly aggressive. However, until now it has not been defined which factors lead to the generation of PD-1 overexpressing subpopulations. Here, we present that melanoma-derived exosomes, conveying oncogenic molecular reprogramming, induce the formation of a melanoma-like, PD-1 overexpressing cell population (mMSC(PD-1+)) from naive mesenchymal stem cells (MSCs). Exosomes and mMSC(PD-1+) cells induce tumor progression and expression of oncogenic factors in vivo. Finally, we revealed a characteristic, tumorigenic signaling network combining the upregulated molecules (e.g., PD-1, MET, RAF1, BCL2, MTOR) and their upstream exosomal regulating proteins and miRNAs. Our study highlights the complexity of exosomal communication during tumor progression and contributes to the detailed understanding of metastatic processes. |
