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Publication : Evidence of CD40L/CD40 pathway involvement in experimental transfusion-related acute lung injury.

First Author  Tariket S Year  2019
Journal  Sci Rep Volume  9
Issue  1 Pages  12536
PubMed ID  31467410 Mgi Jnum  J:297984
Mgi Id  MGI:6479479 Doi  10.1038/s41598-019-49040-0
Citation  Tariket S, et al. (2019) Evidence of CD40L/CD40 pathway involvement in experimental transfusion-related acute lung injury. Sci Rep 9(1):12536
abstractText  Platelet transfusions can cause adverse reactions in their recipients, including transfusion-related acute lung injury (TRALI). The pathophysiology of TRALI depends on a number of signaling pathways and the inflammatory role played by blood platelets remains controversial. Platelets are important in inflammation, particularly via the immunomodulator complex CD40/CD40L. We studied the specific function of the CD40/CD40L interaction in regulating an experimental TRALI Two-hit model. A mouse model of immune TRALI was triggered by injection of LPS and an anti-MHC I antibody, and the effect of injection of a neutralizing anti-CD40L antibody before induction of TRALI investigated. The characteristics of TRALI were decreased body temperature, pulmonary lesions, and immune cell infiltration into the alveolar space. Pulmonary infiltration was evaluated by blood counts of specific immune cells and their detection in lung sections. Inhibition of the CD40/CD40L immunomodulator interaction significantly reduced communication between immune and/or endothelial cells and the development of pulmonary edema. Hence, our results indicate that targeting of the CD40/CD40L interaction could be an important method to prevent TRALI. While considering that our work concerned a mouse model, we postulate that improvement of the conditions under which platelet concentrates are prepared/stored would assist in alleviating the risk of TRALI.
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