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Publication : p27(KIP1) and PTEN cooperate in myeloproliferative neoplasm tumor suppression in mice.

First Author  Shao J Year  2015
Journal  Exp Hematol Oncol Volume  5
Pages  17 PubMed ID  27366593
Mgi Jnum  J:303006 Mgi Id  MGI:6510083
Doi  10.1186/s40164-016-0047-0 Citation  Shao J, et al. (2015) p27(KIP1) and PTEN cooperate in myeloproliferative neoplasm tumor suppression in mice. Exp Hematol Oncol 5:17
abstractText  PTEN acts as a phosphatase for PIP3 and negatively regulates the PI3K/AKT pathway, and p27(KIP1) is a cyclin-dependent kinase inhibitor that regulates the G1 to S-phase transition by binding to and regulating the activity of cyclin-dependent kinases. Genetic alterations of PTEN or CDKN1B (p27(KIP1)) are common in hematological malignancies. To better understand how mutations in these two genes might cooperate in leukemogenesis, we inactivated both genes in the hematological compartment in mice. Here, we show that the combined inactivation of Pten and Cdkn1b results in a more severe myeloproliferative neoplasm phenotype associated with lower hemoglobin, enlarged spleen and liver, and shorter lifespan compared to inactivation of Pten alone. More severe anemia and increased myeloid infiltration and destruction of the spleen contributed to the earlier death of these mice, and elevated p-AKT, cyclin D1, and cyclin D3 might contribute to the development of this phenotype. In conclusion, PTEN and p27(KIP1) cooperate in tumor suppression in the hematological compartment.
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