| First Author | Priya R | Year | 2020 |
| Journal | J Neuroimmunol | Volume | 349 |
| Pages | 577428 | PubMed ID | 33096293 |
| Mgi Jnum | J:299836 | Mgi Id | MGI:6490723 |
| Doi | 10.1016/j.jneuroim.2020.577428 | Citation | Priya R, et al. (2020) Brain astrocytes and microglia express functional MR1 molecules that present microbial antigens to mucosal-associated invariant T (MAIT) cells. J Neuroimmunol 349:577428 |
| abstractText | It is unknown whether brain astrocytes and microglia have the capacity to present microbial antigens via the innate immune MR1/MAIT cell axis. We have detected MAIT cells in the normal mouse brain and found that both astrocytes and microglia are MR1(+). When we stimulated brain astrocytes and microglia with E. coli, and then co-cultured them with MAIT cells, MR1 surface expression was upregulated and MAIT cells were activated in an antigen-dependent manner. Considering the association of MAIT cells with inflammatory conditions, including those in the CNS, the MR1/MAIT cell axis could be a novel therapeutic target in neuroinflammatory disorders. |
