| First Author | Ge C | Year | 2020 |
| Journal | Aging (Albany NY) | Volume | 12 |
| Issue | 6 | Pages | 4836-4865 |
| PubMed ID | 32182211 | Mgi Jnum | J:304699 |
| Mgi Id | MGI:6514548 | Doi | 10.18632/aging.102906 |
| Citation | Ge C, et al. (2020) Nrf2 deficiency aggravates PM2.5-induced cardiomyopathy by enhancing oxidative stress, fibrosis and inflammation via RIPK3-regulated mitochondrial disorder. Aging (Albany NY) 12(6):4836-4865 |
| abstractText | PM2.5 is a well-known air pollutant threatening public health, and long-term exposure to PM2.5 increases the risk of cardiovascular diseases. Nrf2 plays a pivotal role in the amelioration of PM2.5-induced lung injury. However, if Nrf2 is involved in PM2.5-induced heart injury, and the underlying molecular mechanisms have not been explored. In this study, wild type (Nrf2(+/+)) and Nrf2 knockout (Nrf2(-/-)) mice were exposed to PM2.5 for 6 months. After PM2.5 exposure, Nrf2(-/-) mice developed severe physiological changes, lung injury and cardiac dysfunction. In the PM2.5-exposed hearts, Nrf2 deficiency caused significant collagen accumulation through promoting the expression of fibrosis-associated signals. Additionally, Nrf2(-/-) mice exhibited greater oxidative stress in cardiac tissues after PM2.5 exposure. Furthermore, PM2.5-induced inflammation in heart samples were accelerated in Nrf2(-/-) mice through promoting inhibitor of alpha/nuclear factor kappaB (IkappaBalpha/NF-kappaB) signaling pathways. We also found that Nrf2(-/-) aggravated autophagy initiation and glucose metabolism disorder in hearts of mice with PM2.5 challenge. Cardiac receptor-interacting protein kinase 3 (RIPK3) expression triggered by PM2.5 was further enhanced in mice with the loss of Nrf2. Collectively, these results suggested that strategies for enhancing Nrf2 could be used to treat PM2.5-induced cardiovascular diseases. |
