| First Author | Bell ML | Year | 2010 |
| Journal | Mol Cell Biol | Volume | 30 |
| Issue | 8 | Pages | 1937-45 |
| PubMed ID | 20154144 | Mgi Jnum | J:299157 |
| Mgi Id | MGI:6491228 | Doi | 10.1128/MCB.01370-09 |
| Citation | Bell ML, et al. (2010) Uncoupling of expression of an intronic microRNA and its myosin host gene by exon skipping. Mol Cell Biol 30(8):1937-45 |
| abstractText | The ancient MYH7b gene, expressed in striated muscle and brain, encodes a sarcomeric myosin and the intronic microRNA miR-499. We find that skipping of an exon introduces a premature termination codon in the transcript that downregulates MYH7b protein production without affecting microRNA expression. Among other genes, endogenous miR-499 targets the 3' untranslated region of the transcription factor Sox6, which in turn acts as a repressor of MYH7b transcriptional activity. Thus, concerted transcription and alternative splicing uncouple the level of expression of MYH7b and miR-499 when their coexpression is not required. |
