| First Author | Tay RE | Year | 2020 |
| Journal | J Exp Med | Volume | 217 |
| Issue | 7 | PubMed ID | 32374402 |
| Mgi Jnum | J:302518 | Mgi Id | MGI:6508195 |
| Doi | 10.1084/jem.20191453 | Citation | Tay RE, et al. (2020) Hdac3 is an epigenetic inhibitor of the cytotoxicity program in CD8 T cells. J Exp Med 217(7) |
| abstractText | Cytotoxic T cells play a key role in adaptive immunity by killing infected or cancerous cells. While the transcriptional control of CD8 T cell differentiation and effector function following T cell activation has been extensively studied, little is known about epigenetic regulation of these processes. Here we show that the histone deacetylase HDAC3 inhibits CD8 T cell cytotoxicity early during activation and is required for persistence of activated CD8 T cells following resolution of an acute infection. Mechanistically, HDAC3 inhibits gene programs associated with cytotoxicity and effector differentiation of CD8 T cells including genes encoding essential cytotoxicity proteins and key transcription factors. These data identify HDAC3 as an epigenetic regulator of the CD8 T cell cytotoxicity program. |
