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Publication : Crosstown Traffic: Lymphodepleting Chemotherapy Drives CAR T Cells.

First Author  Davies DM Year  2021
Journal  Cancer Cell Volume  39
Issue  2 Pages  138-140
PubMed ID  33417830 Mgi Jnum  J:302329
Mgi Id  MGI:6508325 Doi  10.1016/j.ccell.2020.12.019
Citation  Davies DM, et al. (2021) Crosstown Traffic: Lymphodepleting Chemotherapy Drives CAR T Cells. Cancer Cell 39(2):138-140
abstractText  CAR-engineered T cell immunotherapy has proven transformative in selected hematological malignancies. However, solid tumors largely remain impervious to these approaches. In addressing this challenge, Srivastava et al. in this issue demonstrate that oxaliplatin-based lymphodepleting chemotherapy promotes enhanced CAR T cell recruitment to lung tumors, boosting therapeutic impact in combination with anti-PD-L1.
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