| First Author | Pöysti S | Year | 2021 |
| Journal | Eur J Immunol | Volume | 51 |
| Issue | 3 | Pages | 620-625 |
| PubMed ID | 33078848 | Mgi Jnum | J:304451 |
| Mgi Id | MGI:6508637 | Doi | 10.1002/eji.202048714 |
| Citation | Poysti S, et al. (2021) Plasmacytoid dendritic cells regulate host immune response to Citrobacter rodentium induced colitis in colon-draining lymph nodes. Eur J Immunol 51(3):620-625 |
| abstractText | Dendritic cells (DCs) are first in line to sense invading microbes and to deliver signals to other immune cells. Plasmacytoid DCs (pDC) produce high amounts of type I interferons (IFNs) but also regulate immune responses. Using the Clec4C (BDCA2)-diphtheria toxin receptor mouse model allowing conditional pDC depletion, we identified an essential role for pDCs in regulating intestinal inflammation locally in the gut. In pDC-depleted mice, Citrobacter rodentium infection led to enhanced activation of conventional DCs and induction of IFN-gamma-producing Th1-cells in colon-draining lymph nodes, while induction of Foxp3(+) /CD25(+) Treg and IL-17-producing Th17 cells was impaired. Concomitantly, F4/80(+) macrophages accumulated into the colon lamina propria in excess, and levels of Il-1beta and Tnf transcripts increased and Foxp3(+) Treg were fewer. Our results indicate that pDCs control inflammation in the gut during C. rodentium infection and that they have an important immune regulatory role in colon-draining lymph nodes. |
