| First Author | Matsunaga Y | Year | 2021 |
| Journal | J Immunol | Volume | 206 |
| Issue | 4 | Pages | 766-775 |
| PubMed ID | 33431657 | Mgi Jnum | J:303889 |
| Mgi Id | MGI:6515400 | Doi | 10.4049/jimmunol.2000591 |
| Citation | Matsunaga Y, et al. (2021) Intestinal IL-17R Signaling Controls Secretory IgA and Oxidase Balance in Citrobacter rodentium Infection. J Immunol 206(4):766-775 |
| abstractText | Type 17 cytokines have been strongly implicated in mucosal immunity, in part by regulating the production of antimicrobial peptides. Using a mouse model of Citrobacter rodentium infection, which causes colitis, we found that intestinal IL-17RA and IL-17RC were partially required for control of infection in the colon and IL-17 regulates the production of luminal hydrogen peroxide as well as expression of Tnsf13 Reduced Tnfsf13 expression was associated with a profound defect in generating C. rodentium-specific IgA(+) Ab-secreting cells. Taken together, intestinal IL-17R signaling plays key roles in controlling invading pathogens, in part by regulating luminal hydrogen peroxide as well as regulating the generation of pathogen-specific IgA(+) Ab-secreting cells. |
