| First Author | Buckley TN | Year | 2021 |
| Journal | Am J Physiol Regul Integr Comp Physiol | Volume | 320 |
| Issue | 5 | Pages | R619-R629 |
| PubMed ID | 33626995 | Mgi Jnum | J:313256 |
| Mgi Id | MGI:6515660 | Doi | 10.1152/ajpregu.00150.2020 |
| Citation | Buckley TN, et al. (2021) High-fat feeding disrupts daily eating behavior rhythms in obesity-prone but not in obesity-resistant male inbred mouse strains. Am J Physiol Regul Integr Comp Physiol |
| abstractText | Abnormal meal timing, like skipping breakfast and late-night snacking, is associated with obesity in humans. Disruption of daily eating rhythms also contributes to obesity in mice. When fed high-fat diet, male C57BL/6J mice have disrupted eating behavior rhythms and they become obese. In contrast to obesity-prone C57BL/6J mice, some inbred strains of mice are resistant to high-fat diet-induced obesity. In this study, we sought to determine whether there are distinct effects of high-fat feeding on daily eating behavior rhythms in obesity-prone and obesity-resistant male mice. Male obesity-prone (C57BL/6J and 129X1/SvJ) and obesity-resistant (SWR/J and BALB/cJ) mice were fed low-fat diet or high-fat diet for 6 weeks. Consistent with previous studies, obesity-prone male mice gained more weight and adiposity during high-fat diet feeding than obesity-resistant male mice. The amplitude of the daily rhythm of eating behavior was markedly attenuated in male obesity-prone mice fed high-fat diet, but not in obesity-resistant males. In contrast, high-fat feeding did not differentially affect locomotor activity rhythms in obesity-prone and obesity-resistant male mice. Together, these data suggest that regulation of the daily rhythm of eating may underlie propensity to develop diet-induced obesity in male mice. |
