| First Author | McHugh D | Year | 2020 |
| Journal | Life Sci Alliance | Volume | 3 |
| Issue | 8 | PubMed ID | 32576602 |
| Mgi Jnum | J:304260 | Mgi Id | MGI:6694471 |
| Doi | 10.26508/lsa.202000640 | Citation | McHugh D, et al. (2020) EBV renders B cells susceptible to HIV-1 in humanized mice. Life Sci Alliance 3(8) |
| abstractText | HIV and EBV are human pathogens that cause a considerable burden to worldwide health. In combination, these viruses are linked to AIDS-associated lymphomas. We found that EBV, which transforms B cells, renders them susceptible to HIV-1 infection in a CXCR4 and CD4-dependent manner in vitro and that CXCR4-tropic HIV-1 integrates into the genome of these B cells with the same molecular profile as in autologous CD4(+) T cells. In addition, we established a humanized mouse model to investigate the in vivo interactions of EBV and HIV-1 upon coinfection. The respective mice that reconstitute human immune system components upon transplantation with CD34(+) human hematopoietic progenitor cells could recapitulate aspects of EBV and HIV immunobiology observed in dual-infected patients. Upon coinfection of humanized mice, EBV/HIV dual-infected B cells could be detected, but were susceptible to CD8(+) T-cell-mediated immune control. |
