| First Author | Chaix J | Year | 2014 |
| Journal | J Immunol | Volume | 193 |
| Issue | 3 | Pages | 1013-6 |
| PubMed ID | 24973450 | Mgi Jnum | J:309265 |
| Mgi Id | MGI:6705445 | Doi | 10.4049/jimmunol.1400488 |
| Citation | Chaix J, et al. (2014) Cutting edge: CXCR4 is critical for CD8+ memory T cell homeostatic self-renewal but not rechallenge self-renewal. J Immunol 193(3):1013-6 |
| abstractText | Central memory (CM) CD8(+) T cells "remember" prior encounters because they maintain themselves through cell division in the absence of ongoing challenge (homeostatic self-renewal), as well as reproduce the CM fate while manufacturing effector cells during secondary Ag encounters (rechallenge self-renewal). We tested the consequence of conditional deletion of the bone marrow homing receptor CXCR4 on antiviral T cell responses. CXCR4-deficient CD8(+) T cells have impaired memory cell maintenance due to defective homeostatic proliferation. Upon rechallenge, however, CXCR4-deficient T cells can re-expand and renew the CM pool while producing secondary effector cells. The critical bone marrow-derived signals essential for CD8(+) T cell homeostatic self-renewal appear to be dispensable to yield self-renewing, functionally asymmetric cell fates during rechallenge. |
