| First Author | Trivedi N | Year | 2019 |
| Journal | Immunity | Volume | 51 |
| Issue | 6 | Pages | 1088-1101.e5 |
| PubMed ID | 31732168 | Mgi Jnum | J:305617 |
| Mgi Id | MGI:6706505 | Doi | 10.1016/j.immuni.2019.10.004 |
| Citation | Trivedi N, et al. (2019) Liver Is a Generative Site for the B Cell Response to Ehrlichia muris. Immunity 51(6):1088-1101.e5 |
| abstractText | The B cell response to Ehrlichia muris is dominated by plasmablasts (PBs), with few-if any-germinal centers (GCs), yet it generates protective immunoglobulin M (IgM) memory B cells (MBCs) that express the transcription factor T-bet and harbor V-region mutations. Because Ehrlichia prominently infects the liver, we investigated the nature of liver B cell response and that of the spleen. B cells within infected livers proliferated and underwent somatic hypermutation (SHM). Vh-region sequencing revealed trafficking of clones between the spleen and liver and often subsequent local clonal expansion and intraparenchymal localization of T-bet(+) MBCs. T-bet(+) MBCs expressed MBC subset markers CD80 and PD-L2. Many T-bet(+) MBCs lacked CD11b or CD11c expression but had marginal zone (MZ) B cell phenotypes and colonized the splenic MZ, revealing T-bet(+) MBC plasticity. Hence, liver and spleen are generative sites of B cell responses, and they include V-region mutation and result in liver MBC localization. |
