| First Author | Chen R | Year | 2018 |
| Journal | Int Immunopharmacol | Volume | 63 |
| Pages | 191-197 | PubMed ID | 30099287 |
| Mgi Jnum | J:306431 | Mgi Id | MGI:6708390 |
| Doi | 10.1016/j.intimp.2018.08.009 | Citation | Chen R, et al. (2018) Heme oxygenase-2 suppresses acute inflammation and improves the survival of skin allografts. Int Immunopharmacol 63:191-197 |
| abstractText | The heme oxygenase (HO) system is an important regulatory arm of the intrinsic cytoprotective and anti-inflammatory system. HO-2 plays an important role in regulating inflammation following injury. The aim of this study was to evaluate the effect of HO-2 overexpression on inflammatory responses. A skin transplantation model, involving the application of skin grafts from wild-type or HO-2 overexpressing mice to BALB/c mice, was used for investigation. HO-2 overexpression suppressed the production of pro-inflammatory cytokines (IL-1beta, TNF-alpha, and IL-6) in macrophages compared to that in macrophages obtained from control mice. HO-2 overexpression also significantly prolonged the survival of allografted skin. Our findings suggest that HO-2 attenuates inflammatory responses and effectively prolongs skin graft survival. |
