| First Author | Yan R | Year | 2015 |
| Journal | J Mol Neurosci | Volume | 57 |
| Issue | 4 | Pages | 463-9 |
| PubMed ID | 26130477 | Mgi Jnum | J:306188 |
| Mgi Id | MGI:6709105 | Doi | 10.1007/s12031-015-0608-4 |
| Citation | Yan R, et al. (2015) Spag6 Negatively Regulates Neuronal Migration During Mouse Brain Development. J Mol Neurosci 57(4):463-9 |
| abstractText | Sperm-associated antigen 6 (Spag6) is a Chlamydomonas reinhardtii PF16 homologous gene detected in the human testis and is crucial for sperm motility. Neuronal migration is a dynamic process requiring coordinated cytoskeletal remodeling, and Spag6 is co-localized with microtubules in Chinese hamster ovary cells and COS-1 cells. However, the role of Spag6 in neuronal migration remains unclear. Here, we demonstrated that Spag6 was continuously expressed in the developing cerebral cortex. Using in utero electroporation (IUE), we found that overexpression of Spag6 delayed the rate of neuronal migration, rather than affecting the ultimate fate of cortical neurons. Furthermore, overexpression of Spag6 caused a significant decrease in neurite number and length of cortical neurons. Our results indicated that Spag6 controlled neuronal migration as well as neurite branching and elongation. |
